【摘 要】
：
Background:Drug eluting stents reduce neointima growth and revascularization rates but at the expense of delaying re-endothelialization (RE) of the stented artery and as a result may place patients at
【机 构】
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University of Ottawa Heart Institute Canada
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Background:Drug eluting stents reduce neointima growth and revascularization rates but at the expense of delaying re-endothelialization (RE) of the stented artery and as a result may place patients at risk for stent thrombosis.Recently,we demonstrated that pharmacological expansion and functional enhancement of endothelial progenitor cells (EPCs) can be achieved with a glycogen synthase kinase 3-beta inhibitor (GSKi).Indeed,dose dependant GSKi-related improvements in EPC yield and survival were even produced in feeble cells from patients with CAD-in part related to a reduction in apoptosis.Moreover,GSKi treatment enhanced EPC adhesion via the upregulation of the α-4 integrin subunit.Purpose:We hypothesized that local delivery of GSKi via a coated stent may result in enhanced arterial repair.Methods/Results:First the in vitro effects of drug coating on EPC attachment to stents were studied.
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