The Relationship between Cerebral Amyloid Angiopathy and Intracranial Hemorrhage

• 机 构: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, Ch
• 出 处: 北京医学会神经外科学分会暨北京医师协会神经外科专业专家委员会2010年北京神经外科年会
• 发表日期: 2011年7期
• 关键词: Cerebral Amyloid Angiopathy (CAA) Intracranial Hemorrhage(ICH) Hypertension apoE

　　Objective To investigate the incidence of cerebral amyloid angiopathy (CAA) in surgically treated spontaneous intracranial hemorrhage (ICH) in China,and to explore the possible relationship between hypertension and CAA in the process to ICH.Materials and Methods During the period May 2008 and March 2009,680 patients admitted to 55 hospitals throughout China for acute spontaneous ICH were studied.Emergent craniotomy for hemorrhage evacuation was performed for these patients within 72 hours after hemorrhage onset and brain tissue of both the suspected residual hemorrhage cavity and cortex was obtained as well.A further histological study,Congo red stained and Aβ immunochemistry included was followed to verify the existence of CAA.Results Fifteen samples out of the 680 cases were identified as CAA positive,and the total ratio is 14.29%.As to age groups,about 20.83% (5/24) of the cases of the 40-49 years old group have been diagnosed as CAA,17.14% (6/35) of the 50-59years old group,4.17% (1/24) of the 60-69 group,and for those older than 70 years,the ratio is 8.00% (2/25).Conclusions About 14.29% of the ICH events might be due to CAA based on our study.And more men than women are suffered from ICH.As to CAA,however,the incidence ratio between men and women is 8 to 7.We come to a different conclusion comparing to those published reports based on autopsy.The age group with highest incidence of CAA-ICH is between 40-59 years,and the poor prognosis of ICH as well as the treatment preferences between the old and the rest of the population may be the leading causes of differences according to our knowledge.