49.Diffusion tensor imaging for predicting the clinical outcome of delayed encephalopathy of acute c

• 作 者: 侯晓敏[1]马琳琳[1]武连华[1]张奕[1]葛环[1]李茁[1]高宇[1]周立荣[2]高春锦[1]
• 机 构: 首都医科大学附属北京朝阳医院高压氧科
• 出 处: 中华医学会第二十一次全国高压氧医学学术会议
• 发表日期: 2012年期

Objective The aim of the present study was to determine the relationship between neuropsychiatric outcomes and diffusion tensor imaging (DTI) in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP).Methods and Materials 66 patients and 60 healthy controls were included in this study.Median fractional anisotropy (FA) of the white matter bilaterally was compared between patients and healthy controls.The Glasgow outcome scale (GOS) was assessed at four to six months following DEACMP.The association between the GOS score and FA variables was explored using the Spearman rank correlation.Results The FA values in white matter were reduced in patients with DEACMP compared with those in the volunteers.Of the 66 patients,21 (31.8％) achieved a good outcome (GOS-5),26 (36.4％) had moderate disability (GOS-4),14 (21.2％) had severe disability (GOS-3),5 (7.6％) were in a vegetative state (GOS-2),and none of the patients died (GOS-1).The FA values in the white matter in patients with DEACMP correlated significantly with GOS.Conclusion DTI may be a valuable tool for assessing the severity of tissue injury and may be a predictor of outcome.