Pharmacokinetics of low dose glibenclamide in rats with mild hypothermia

• 作 者: XingLi;Su-YuePan;
• 机 构: Department of Neurology, Nanfang Hospital, Southern Medical University, P.R.China
• 出 处: 广东省医学会第十七次神经病学学术会议暨第七届粤港澳神经病学学术会议
• 发表日期: 2015年期

　　Background and Purpose: Preclinical and clinical studies indicate that low dose glibenclamide exhibits pleiotropic protective effects by inhibiting the SUR1-TRPM4 channel in different CNS pathologies.Data in our laboratory showed that glibenclamide enhanced the efficacy of mild hypothermia both in vivo and in vitro.But the pharmacokinetics of low dose glibenclamide in rats with mild hypothermia is still unknown.