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Objectives Daunorubicin causes cardiac injury in acute nonlymphocytic leukemia.Early identifying caridotoxicity induced by daunorubicin might help individualise cardiac protect treatment.Dexrazoxane can reduce cardiac damage.In this study, we assess the left ventricular function in patients with acute nonlymphocytic leukemia who had daunorubicin treatment with or without in combination with dexrazoxane.