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Peptide hydrazides are masked form of peptide thioesters which can be activated efficiently and ligated with Cys-peptides[1].However,peptide hydrazides were found to be incompatible with Thz,a widely used protected form of Cys in protein chemical synthesis,for Thz is unstable under the activating condition for peptide hydrazides.Here a modified form of Thz,Tbeoc-Thz,was developed as a novel protected Cys in protein chemical synthesis.Tbeoc-Thz is stable under the activating condition for peptide hydrazides and can be converted to Thz under reducing conditions.