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Because of the potential public health risk posed by the rapidly expanding array of engineered nanomaterials (ENMs) currently in use in many consumer products and industrial applications, high-throughput in vitro methods for safety assessment are sorely needed, but to date have not proven reliable in predicting toxicological outcomes in animal models. One of the important reasons for this discordance is the failure to reconcile in vitro with in-vivo doses and link them to ―real world‖ ENM exposure levels. Furthermore, despite growing evidence of the importance of dosimetry in in vitro hazard ranking, very few studies take it into consideration.