Overexpression of SIRT6 in the hippocampal CA1 impairs the formation of long-term contextual fear me

• 作 者: XiYin[1]YuanGao[2]LiSong[2]Jie-ChaoWang[3]Xu-HongGeng[1]Hai-ShuiShi[2]
• 机 构: Department of Functional region of Diagnosis,Hebei Medical University Fourth Hospital,Hebei Medical
• 出 处: 第五届泛环渤海生物化学与分子生物学会学术交流会
• 发表日期: 2015年期

　　Histone modifications have been implicated in learning and memory.Our previous transcriptome data showed that expression of sirtuins 6(SIRT6),a member of Histone deacetylases(HDACs)family in the hippocampal CA1 was decreased after contextual fear conditioning.