β4GalT1 regulates the N-glycosylation of BMP2 and TNFR1 to promote microglial inflammatory activatio

• 作 者: Dongmei Zhang Chi Sun Lijian Han Aiguo Shen
• 机 构: JiangsuProvinceKeyLaboratoryforInflammationandMolecularDrugTarget;NantongUniversity,Nantong,226001,P
• 出 处: 2016年全国糖生物学学术会议
• 发表日期: 2016年8期
• 关键词: microglia N-glycosylation β4GalT1 BMP-2 TNFR1

　　Microglial inflammatory activation,as the center of neuroinflammation,greatly contributes to diverse neurodegenerative disorders.β1,4-Galactosyltransferase-Ⅰ(β4GalT1),a member of β-1,4-Galactosyltransferase gene(β4GalT)family,reportedly promotes microglial inflammatory activation,but the underlying molecular mechanisms remain unclear.