ENHANCEMENT OF VALIDAMYCIN A PRODUCTION BY H2O2-INDUCED REACTIVE OXYGEN SPECIES IN FERMENTATION OF S

来源 :15th International Symposiium on the Biology of Actinomycete | 被引量 : 0次 | 上传用户：q_yong

【摘要】

：

【作者】

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Zhenhua Wei Linquan Bai Zixin Deng Jian-Jiang Zhong

【机构】

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State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shang

【出处】

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15th International Symposiium on the Biology of Actinomycete

【发表日期】

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2009年12期

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　　Reactive Oxygen Species (ROS)mediatu many cell processes in bacteria and ROS induction has been employed as a novel strategy to improve the production of secondary metabolite.In this work,H2O2 was used as an ROS generator to investigate its effect on VAL-A production.VAL-A production was enhanced by 38% on day 4 when 25 μM H2O2 was added to the medium at 8 h during fermentation.ROS inhibitor diphenylene iodonium(DPl)was used to study the effect of ROS on VAL-A production in Streptomyces hygroscopocus 5008 (5008) wild type and valP/Q mutant strains.

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