DP1, one of prostaglandin D2 receptors, expression in intestinal epithelial cell, myeloid and endoth

• 作 者: JuanjuanLi;
• 机 构: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences,Shanghai Institutes f
• 出 处: 2014 International Symposium on Polyunsaturated Fatty Acids
• 发表日期: 2014年期

　　Adverse effects of pharmacological inhibition of cyclooxygenase (COX) in colitis patients were reported.PGD2, one of downstream product of COX, was also seen as a pro-resolution factor in the development of colitis.But the role of its one of receptors, DP1,which mainly regulating the anti-inflammatory reaction, is less well understood.We investigated the expression of DP1 in biopsies from colitis patients and DSS-treated mice.The expression of DP1 was measured by immunofluorescence staining.The effect of DP1 in colitis was evaluated in a murine colitis model induced by dextran sulfate sodium (DSS).