【摘 要】
：
目的:观察米诺环素对脊髓背角Ⅱ层胶状质(substantia gelatinosa,SG)神经元的影响及其机制.方法:选取3～5周龄的雄性SD大鼠,制作离体脊髓横/纵切片(300μm),应用全细胞膜片钳技术记录SG神经元超级化激活电流(hyperpolarization-activated current,Ih),灌流不同浓度的米诺环素(1～300 mol/L)并观察其对Ih的影响.
【机 构】
：
南昌大学第一附属医院疼痛科,南昌330006 南昌大学第一附属医院儿科,南昌330006
【出 处】
：
中华医学会疼痛学分会第十一届学术年会
论文部分内容阅读
目的:观察米诺环素对脊髓背角Ⅱ层胶状质(substantia gelatinosa,SG)神经元的影响及其机制.方法:选取3～5周龄的雄性SD大鼠,制作离体脊髓横/纵切片(300μm),应用全细胞膜片钳技术记录SG神经元超级化激活电流(hyperpolarization-activated current,Ih),灌流不同浓度的米诺环素(1～300 mol/L)并观察其对Ih的影响.
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