Subcutaneous rotenone exposure causes selective dopaminergic degeneration and behavioral alterations

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户：xiongmao_yang

【摘要】

：

The systemic rotenone model of PD accurately replicates many aspects of the pathology of human PD.However,the major limitation of the rotenone model has been its variability in terms of the extend of

【作者】

：

Li Zhang Li-Min Liu E Lv Lin Dong Rui-Jun Su Xiao-Li Gong Ya-Long Wang Yan-Jing Qian Zhao-Xia Zhang Xiao-Min Wang

【机构】

：

Departments of Neurobiology and Physiology,Key Laboratory for Neurodegenerative Disorders of the Min

【出处】

：

The 6th FAONS Congress and 11th Biennial Conference of CNS(第

【发表日期】

：

2015年3期

【关键词】

：

Rotenone Parkinson’s disease Rat Behaviors Dopamine

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　The systemic rotenone model of PD accurately replicates many aspects of the pathology of human PD.However,the major limitation of the rotenone model has been its variability in terms of the extend of nigrostriatal,and high mortality of animals.

其他文献

Exendin-4 improves circadian rhythm disorders induced by Aβ31-35 in C57 mouse models

Alzheimers disease(AD)is an age-related neurodegenerative disorder,and characterized by chronic progressive deterioration of cognition,learning and memory.

会议

Alzheimer’s diseaseExendin-4circadian rhythm

Effect of electro-acupuncture on Aβ and LRP1 in hippocampus of APP/PS1 transgenic mice

Beta-amyloid(Aβ)cascade theory is the most recognized pathogenesis of Alzheimers disease(AD).

会议

Electro-AcupunctureAlzheimer’s diseaseβ amyloid proteinlow density lipoprotei

The effect of estrogen on iron metabolism in astrocytes and neurons

Precious studies have demonstrated that estrogen affects iron metabolism in peripheral tissues.

会议

AstrocyteNeuronestrogenIron

Mammalian target of rapamycin:an efficient therapeutic target for Alzheimer's disease

会议

mTORAlzheimer’s diseaseAβ pathologytherapy

Intranasal administration of Exendin-4 antagonizes circadian rhythm disorders induced by Aβ31-35

Alzheimers disease(AD)is a degenerative disorder of the central nervous system,which often impairs learning and memory,emotion and cognitive function.

会议

Alzheimer’s diseasecircadian rhythmExendin-4

ɑ-Synuclein-induced internalization of NMDA receptors in hippocampal neurons is associated with redu

Abnormal α-synuclein(α-syn)expression and aggregation have been implicated in the pathogenesis of Parkinsons disease(PD),dementia with Lewy bodies(DLB),and Alzheimers disease(AD).

会议

α-synucleinhippocampal neuronsNMDA receptorRab5Binternalization

Tetramethylpyrazine nitrone protects retinal ganglion cells against N-methyl-D-aspartate induced inj

会议

Increased oligomerization and phosphorylation of α-synuclein are associated with decreased activity

Aging is associated with an increased risk for Parkinsons disease(PD)and dementia with Lewy bodies(DLB),in which alpha-synuclein(α-syn)oligomerization plays key pathogenic roles.

会议

α-synucleinParkinson’s diseasedementia with Lewy bodiesglucocerebrosidasecyn

Research on the neuroprotective effects of CI-1206 in an APP/PS1 mouse model

Objective Alzheimer disease(AD)is a fatal neurodegenerative disorder characterized by progressive cognitive impairment and memory loss.

会议

CI-1206APP/PS1 mouseMorris water mazelong term potentiationAlzheimer’s disea

Wirelessly programmable optical stimulation system for optogenetics

Objectives: Optogenetics technology are able to conduct neuromodulation with high selectivity and high spatiotemporal resolution.

会议

optical stimulationoptrodeoptogeneticsneuromodulationwireless

Subcutaneous rotenone exposure causes selective dopaminergic degeneration and behavioral alterations

其他学术论文