Radio-protective effect of hydrogen-rich water in mice

• 作 者: QinXiujun;YinJingjing;XuWenli;SunGe;LiJianguo;AnQuan;LiWeibin;WenJianhua;
• 机 构: Department of Radiation Medicine and Environment Medicine,China Institute for Radiation Protection,T
• 出 处: 第二届全球华人辐射研究大会
• 发表日期: 2014年期

　　Objective To observe the protective effect of hydrogen-rich water on radiation injury in mice,so that could provide scientific basis for the application of hydrogen-rich water.Methods The ICR mice were randomly divided into control group,irradiation group [H2(-)] and hydrogen-rich water group [H2(+)].Animals were whole-body irradiated by 9.0 Gy 60Co-gamma rays.Blood samples of mice were collected from orbital sinus with ether anesthesia at 24 h after irradiation.These samples were centrifuged at 2500 rpm for 15min after coagulation and the serums were separated.The T-SOD,GSH-PX,MDA,GM-CSF,HSP-70 and 8-OHdG were analyzed.Results The results were compared to the H2(-) group.The T-SOD,GSH-PX of the H2(+) group were higher than the H2(-) group (P<0.05),but there was no significance in the MDA (P>0.05).The GM-CSF and HSP-70 of the H2(+) group were higher than the H2(-) group but with no significance (P>0.05).The 8-OHdG of the H2(+) group were lower than the H2(-) group (P<0.05).Conclusion Hydrogen-rich water has anti radiation effect through anti-oxidation,increasing HSP70,GM-CSF,decreasing 8-OHdG.