【摘 要】
：
A novel organic-inorganic hybrids,the so-called cerasomes has been synthesized by combination of sol-gel reaction and self-assembly of a molecular which is analogous to lipids.Firstly,the cerasome for
【机 构】
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Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Enginee
【出 处】
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全国药物化学学术会议暨第四届中英药物化学学术会议
论文部分内容阅读
A novel organic-inorganic hybrids,the so-called cerasomes has been synthesized by combination of sol-gel reaction and self-assembly of a molecular which is analogous to lipids.Firstly,the cerasome forming lipid(compound 1)was synthesized with 3-Iopdopropyl trimethoxysilane and compound 2 which was synthesized by referring the reported route[1] in dry DMF(route 1).Secondly,this synthesized lipid was used to fabricate cerasome,thereby investigating the self-assembly capability to form vehicles.Logically,like other similar compounds[2],it can form cerasome with a bilayer vesicular structure and a silicate surface.Of note,the yield was higher than any other analogous published in the literature,and the whole process of forming cerasome was in distilled water at a pH ranged from 2 to 12,which is much wide than that of reported molecules.Finally,encapsulation of ICG which is a fluorescent dye was carried out,which resembles that of making blank cerasomes,excepting that ICG chloroform solution was added at the film forming step.
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