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Kaposis sarcoma associated herpesvirus (KSHV) primarily infects a variety of target cells such as endothelial cells, B cells, monocytes, epithelial cells, and keratinocytes and establishes lifelong latency in many of these cell types.Although the expression of latent proteins are critical in inducing and maintaining KSHV latency, the infected cells are primed early on during primary infection to induce tumors and maintain viral genomes.