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Guangdong Province is located in subtropical zones in the southern China,has a sericulture history of more than 2,000 years,which produced the sericulture world record-breaking annual amount of rearing silkworm and the annual cocoon yield of unit area.The Guangdong Silk-Tex.Corporation Group,which is a province-owned and trade-industry-agriculture-integrated corporate group,in cooperation with University and Institute,promotes the trade-oriented rational development of sericulture in Guangdong,and takes the lead in the silk industry as one of the top 200 biggest import and export enterprises in China.This paper reviewed the development of sericulture in Guangdong within the recent period.It will look back the Changes of sericulture over two decades in Guangdong,which included Succeeding in the strategic transformation of sericulture area and contributing to the prosperity of poor areas and foreign exchange-earning,and making huge improvement on the quality of silk by achieving bivoltine rearing all year around.Consequently,Guangdong could select bivoltine breeds suitable for room rearing according to climate condition and mulberry growth.Here we also will share the successful experiences of developing sericulture in Guangdong.The results show that sericultural science and technology serves as a key point to maintain sustained development and promote sericulture in Guangdong.During the past 30 years,research,education and productive branches in Guangdong,in close cooperation,have conducted comprehensive research on selection and breeding of mulberry trees and silkworms,technologies of mulberry cultivation and silkworm rearing,disease prevention and combined utilization of sericulture resource.The major achievements that greatly promote sericulture development in Guangdong are as follows,upgrading the mulberry breed,introduction of excellent silkworm varieties,regulating and innovating on breeding technologies of healthy varieties,developing a series of disinfection and treating chemicals,building and promoting a high-quality and high-yielding sericultural technology system.