Association of CYP3A5*3 with Acute Lymphoblastic Leukemia Susceptiveness in Chinese Han Children

• 作 者: YanLiu[1]Xiao-tongLu[1]QiSheng[2]Huai-pingTian[1]A-jingXu[1]Yue-nianTang[1]Shu-hongBu[1]Li-xiaLi[1]JianZhang[1]
• 机 构: Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai,
• 出 处: 2011年中国药学大会暨第11届中国药师周
• 发表日期: 2011年期

To investigate the association of CYP3A5*3 with acute lymphoblastic leukemia susceptiveness in Chinese han children. Methods: CYP3A5 genotype was analyzed from 172 Chinese han children, including 52 acute lymphoblastic leukemia patients and 120 healthy. PCR-RFLP was used to identify the polymorphism. Results: The allelic frequency of CYP3A5*3 was 0.721 (95％ CI: 0.549, 0.893) in patients while 0.758 (95％ CI: 0.674, 0.842) in healthy controls. No significant difference existed in CYP3A5*3 frequencies between patients and controls (P=0.275), males and females (P=0.432) in the total population. Conclusion: The CYP3A5*3 variant represents a common polymorphism in Chinesehealthy children and ALL, and this polymorphism is poor association with childhood acute lymphoblastic leukemia susceptiveness.