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The aims of this study are to investigate the transport pathways of chelator catechol-3,6-bis(methyleneimino-diacetic-acid) calcium disodium salt (CBMIDA-CaNa2) into human renal tubular cells and interaction of CBMIDA-CaNa2 with endogenous metallothionein (MT) in uranium(U(Ⅵ))-induced HK-2 renal proximal tubular epithelial cells damage.