【摘 要】
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Context: Cancer pain is hard to be controlled and usually influences life quality of the patients.Diminishing pain and improving symptoms are the important component of cancer treatment Objectives: Th
【机 构】
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Department of Oncology, Wuhan General Hospital of Guangzhou Command, People’s Liberation Army, Wuhan
【出 处】
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湖北省抗癌协会青年委员会第五届青年学术论坛
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Context: Cancer pain is hard to be controlled and usually influences life quality of the patients.Diminishing pain and improving symptoms are the important component of cancer treatment Objectives: The aim of this study was to investigate the analgesic effects of the combination of flurbiprofen axetil and opioids for the refractory pain in cancer patients.Methods: A total of 144 patients were included in this study.Based on the patients’ wills and following the inclusion/exclusion criteria,46 patients received flurbiprofen axetil injection only,45 patients were enrolled in the flurbiprofen axetil/MS Contin (180mg/24h) group,and the other 53 patients received the combination of flurbiprofen axetil and duragesic (12.6mg/72h).7 days later,pain relief,life quality improvement and side effects were evaluated.Results: With flurbiprofen axetil/opioids combination,the total effective rate rose to 84.6% in flurbiprofen axetil/morphine group and 89.1% in flurbiprofen axetil/fentanyl group,but 60.0% when flurbiprofen axetil single-use.The analgesic effects were increased with the combination of flurbiprofen axetil and fentanyl (X2=9.394,P=0.002) or morphine (X2=5.667,P=0.017).Furthermore,the side effects,such as abdominal pain alimentary tract bleeding which were found in using NSAIDs did not be found.Conclusion: Intravenous flurbiprofen axetil could increase the analgesic effects of duragesic or morphine sulfate sustained-release tablets,and the flurbiprofen axetil/opioids combination could also provide few side effects and accomplish painless survival in cancer patients.
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