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目的：探讨喹啉羧酸类喹诺酮抗生素的光促反应特性。方法：用差示光照量热分析法，并结合ＨＰＬＣ等分析手段，分析光促反应产物产生的时间顺序，比较几个喹诺酮类药的光促反应特性。结果：喹啉羧酸类喹喏酮抗生素的光促反应为放热反应；在溶液中，光促反应具有自身抑制作用，并可被组氨酸所抑制；光不仅可以使喹诺酮抗生素分解，而且可能导致药物聚合；分解反应主要和药物７ 位侧链的哌嗪基有关，且在光照的初期即可发生，而聚合物则需在光照的后期才出现；光促反应为分步反应。结论：１，８萘啶羧酸类药物较喹啉羧酸类药物都有较强的光反应特性。
Objective: To investigate the photoproductive properties of quinolinic acid quinolone antibiotics. Methods: Differential thermal analysis method was used to analyze the time sequence of photoproduction products, and the photoproduction characteristics of several quinolones were compared. Results: The photoproduction of quinolonecarboxylic acid quinolone antibiotics was an exothermic reaction. In the solution, photopoietic reaction had self-inhibitory effect and was inhibited by histidine. Not only did quinolone antibiotic decompose, but also Which may lead to the polymerization of the drug. The decomposition reaction is mainly related to the piperazinyl group in the side chain of the 7-position of the drug, and occurs at the initial stage of light irradiation. However, the polymer needs to appear at the later stage of light irradiation. The photodynamic reaction is a step reaction. CONCLUSION: 1,8-naphthyridine carboxylic acids have stronger photoreaction properties than quinoline carboxylic acids.