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目的：研究复方氯唑沙宗片剂中氯唑沙宗和对乙酰氨基酚的含量测定方法。方法：同时采用ＣＰＡ矩阵法（简称ＣＰＡ法）和多波长线性回归法（简称ＷＭＬ法）测定复方氯唑沙宗片剂中氯唑沙宗和对乙酰氨基酚的含量。并应用计算药学中ＢＡＳＩＣ语言编制计算程序。结果：ＣＰＡ法的氯唑沙宗和对乙酰氨基酚的平均回收率和ＲＳＤ分别为９９．８３％，０．１２％，９９．８７％，０．１４％；ＷＭＬ法的氯唑沙宗和对乙酰氨基酚的平均回收率和ＲＳＤ分别为９８．６７％，０．３４％；１００．０５％，０．３１％（ｎ＝５）。结论：两种方法同时测定两组分的含量，方法简便易行、快速，测定结果可相互校验对比。
Objective: To study the determination of chlorzoxazone and acetaminophen in the compound chlorzoxazone tablets. Methods: The chlorzoxazone and paracetamol contents of compound chlorzoxazone tablets were determined by CPA-matrix method (CPA method for short) and multi-wavelength linear regression method (WML method for short). And the application of computational medicine BA SIC language calculation program. Results: The average recoveries and RSDs of chlorzoxazone and acetaminophen in CPA were 99.83%, 0.12%, 99.87% and 0.14%, respectively. The chlorzoxazone and The average recoveries and RSDs for paracetamol were 98.67%, 0.34%, 100.05% and 0.31%, respectively (n = 5). Conclusion: The two methods for simultaneous determination of the content of two components, the method is simple and easy, fast, the results can be checked and compared with each other.