An innovative strategy to design scoring functions for near native protein-protein interface recogni

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户：Glorygwj

【摘要】

：

Theoretical prediction of the structure of protein-protein complexes remains an outstanding question.One of the difficulties is that how to recognize the near native protein-protein interfaces from a

【作者】

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杨雍逍龚新奇

【机构】

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中国人民大学数学科学研究院,北京100872

【出处】

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第七届全国生物信息学与系统生物学学术大会

【发表日期】

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2016年8期

【关键词】

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Designing Scoring Functions Effective Interface Area Near Native Interface Recog

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　　Theoretical prediction of the structure of protein-protein complexes remains an outstanding question.One of the difficulties is that how to recognize the near native protein-protein interfaces from a large number of docking decoys efficiently.A variety of scoring functions to overcome this difficulty have been designed according to the interface properties such as shape complementarity,electrostatics and desolvation.Some of these scoring functions also used the predicted interface information,the discriminative ability strongly depended on the reliability of predicted interface information.

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An innovative strategy to design scoring functions for near native protein-protein interface recogni

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