表观遗传调控-组蛋白甲基转移酶(EZH2)在免疫细胞功能中的非表观遗传调控作用

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：mbqgg

【摘要】

：

淋巴器官中免疫稳态的一个显著特征是需要少量固有免疫细胞和大量的适应性免疫细胞共同维系,其中固有免疫细胞可以持续的产生细胞因子,而初始的适应性免疫细胞接触到同源性抗原时可活化.一旦这种平衡打破后可导致适应性免疫细胞的过度活化和自身免疫反应.本研究中,我们发现组蛋白甲基转移酶-Ezh2(Enhancer of zeste homolog 2)可通过非经典途径维持免疫稳态.T细胞特异性缺失Ezh2可引起

【作者】

：

李真丁沐阳孟巧红应航洁史丽云许大康

【机构】

：

杭州师范大学医学院衰老研究所

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

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