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目的:张应变调控的血管平滑肌细胞(VSMCs)增殖和分化异常在高血压血管重建(remodeling)病理机制中起到重要作用。然而,VSMCs感受应力刺激,调控细胞功能的力学生物学机制仍不明了。方法:应用FX-4000T细胞张应变加载系统,对
OBJECTIVE: Abnormal proliferation and differentiation of tensile-regulated vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of remodeling of hypertension. However, the mechanistic biological mechanisms by which VSMCs sense stress stimulation and regulate cell function remain unclear. Methods: The strain system of FX-4000T cells was loaded