【摘 要】
：
[目的]观察视网膜神经纤维层厚度(RNFL)在特发性快动眼睡眠期行为障碍(iRBD)患者与帕金森病(PD)患者之间的关联与异同点.[方法]采用高分辨率光相干断层扫描光学相干断层扫描(Cirrus HD-OCT)对入组的10例特发性RBD患者(19眼),24例PD伴RBD患者(48眼),35例PD不伴RBD患者(70眼),27例健康对照组(54眼)进行以视盘中心为圆心、直径为3.46mm的圆周的RN
【机 构】
：
苏州大学附属第二医院神经内科;苏州大学附属第二医院睡眠中心 苏州大学附属第二医院神经内科;苏州大学
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[目的]观察视网膜神经纤维层厚度(RNFL)在特发性快动眼睡眠期行为障碍(iRBD)患者与帕金森病(PD)患者之间的关联与异同点.[方法]采用高分辨率光相干断层扫描光学相干断层扫描(Cirrus HD-OCT)对入组的10例特发性RBD患者(19眼),24例PD伴RBD患者(48眼),35例PD不伴RBD患者(70眼),27例健康对照组(54眼)进行以视盘中心为圆心、直径为3.46mm的圆周的RNFL扫描,计算各组平均、各象限RNFL厚度.特发性RBD患者均由我院睡眠中心行睡眠监测确诊；所有入组PD的患者均通过RBDSQ量表进行RBD筛选,RBDSQ＞6分的确定为临床可能的PD伴RBD患者(PD+RBD),RBDSQ ≤6分的确定为PD不伴可能的RBD患者(PD-RBD),PD患者均详细询问美多芭等芭药物治疗史,疾病的病程,并进行H-Y分期及UPDRS第三部分评分.单因素回归分析四组受检者各象限及时钟点RNFL厚度及平均RNFL厚度的差异,多重线性回归分析RBDSQ评分与RNFL的相关性.
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