Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Recevin

来源 :第十七届全国临床肿瘤学大会暨2014年CSCO学术年会 | 被引量 : 0次 | 上传用户:shenloa
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的: This research aimed to investigate the association between POU5F1P1 (POU class5 homeobox 1 pseudogene 1 gene) rs10505477 polymorphism and the prognosis of Chinese gastric cancer patients, who received cisplatin-based chemotherapy after surgical resection.方法: We first genotyped POU5F1P1 rs 10505477 using the SNaPshot method in 944 gastric cancer patients who received gastrectomy.Then we statistically analyzed the association of rs 10505477 G > A polymorphism with the progression and prognosis in gastric cancer patients by using SPSS version 18.0 for Windows.
其他文献
晚期口腔颌面-头颈鳞癌的治疗仍然是个巨大的挑战.尽管传统的手术、放疗及化疗近年来都取得了很大的进展,但晚期口腔颌面-头颈癌的预后仍然较差,分子靶向药物的兴起为此带来了希望.目前针对头颈癌的靶向治疗的靶点主要有表皮生长因子受体及血管内皮生长因子受体,前者的代表药物有西妥昔单抗及尼妥珠单抗,他们无论是单药治疗,还是与放化疗结合治疗,均表现出了良好的前景;后者的代表药物主要是贝伐单抗,也已经进行到临床Ⅲ
会议
目的:探讨家族性非髓样甲状腺癌(familialnon-medullarythyroidcancer,FNMTC)的临床病理特征,以及3例及3例以上患者家系是否较2例患者家系的临床病理特征更具有侵袭性,3例或3例以上患者、同时累及两代的家系是否比其他家系更具有侵袭性.方法:收集北京协和医院2009年1月至2013年7月间诊治的家族性非髓样甲状腺癌27个家系、55例患者,回顾分析其临床病理资料,比较
会议
Objective: We performed a meta-analysis of cohort studies to determine whether promoter methylation of death-associated protein kinase (DAPK) gene contribute to the pathogenesis of non-small cell lung
会议
Objective: Lung cancer is an important and widespread disease that constitutes a major public health problem, but early detection of small cell lung cancer can significantly improve the survival rate
会议
Objective: Epidermal growth factor receptor (EGFR) mutations and echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) define specific molecular subsets of lung adenoc
会议
Objective: Lung cancer remains the leading cause of cancer related death in men and women worldwide, with nearly 1.4 million deaths each year.Therefore, its very important to develop new treatment str
会议
Objective: Increasing evidence shows that dysregulation of microRNAs (miRNAs) is involved in malignant transformation.We investigated the clinical significance of miR-650 and its involvement in chemor
会议
Objective: Lung cancer is the commonest malignant tumor worldwide, and its average survival is less than one year in advanced patients, so palliative care is especially important in these patients.The
会议
Objective: Objective: In our previous study, secreted protein dihydrodiol dehydrogenases (DDH) and platinum-resistance have been linked.And DNA synthesis and damage repair genes may predict the outcom
会议
Objective: EGFR mutation is a strong predictor of EGFR-TKIs (epidermal growth factor receptor tyrosine kinase inhibitor) therapy in advanced NSCLC.Although as many as 20-30% of EGFR-mutant cases EGFR
会议