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The non-MHC restricted cytotoxicity mediated by bispecific antibody (BiAb) armed anti-CD3 activated T cells (aATC) redirects non-MHC restricted cytotoxicity.Preclinical studies show that anti-CD3 × anti-Her2 (Her2Bi) or anti-CD3 × anti-CD20 (CD20Bi) aATC can kill breast cancer and lymphoma targets, secrete cytokines /chemokines, and proliferate.