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MicroRNAs are a class of naturally occurring small non-coding RNAs that control gene expression at the post transcriptional level.Hence, they can play a fundamental role in regulation of diverse cellular processes such as cell growth, proliferation, differentiation and apoptosis and deregulation of microRNA expression can lead to a variety of disorders including breast cancer.In particular, aberrant expression of microRNAs is associated with disease stages or metastasis status, and unique microRNA signatures for a specific type cancer have been shown to be potential markers to predict clinical outcomes.It is well known that microRNAs may function as either oncogenes or tumor suppressors.In support of this notion, our lab shows that miR-21 is an oncogenic microRNA promoting breast tumor growth and metastasis in by targeting multiple tumor suppressors such as TPM 1, PDCD4 and maspin.Suppression of miR-21 by antagomir can significantly reduce both breast tumor growth and metastasis, as well as sensitize tumor cells to anticancer agents.On the other hand, miR-145 functions as a tumor suppressor by targeting c-Myc and Mucl.