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The detection property of natural drug-curcumin (1) was firstly reported by us.Experimental details showed 1 acts as an excellent UV-Vis and fluorescent selectivity,sensitivity probe for the detection of hypochlorous acid,while other reactive oxygen species (ROS) and reactive nitrogen species (RNS) induced no changes in UV-Vis spectra and fluorescence quench properties of 1.A possible detection mechanism is that HOC1 oxidized phenol of 1 into quinone resulting in a nonfluorescent curcumin derivative.Furthermore,the ability of probe to detect ClO-in living cells was also evaluated (HepG2 cells) via an cancellation of the fluorescence.Moreover,the application of 1 in quantitative analysis of hypochlorite in 84 disinfectant was also illustrated..