LC-MS/MS方法测定大鼠脑中9种非标记PET显像剂的浓度

来源 :2018年中国质谱学术大会 | 被引量 : 0次 | 上传用户：tian314714

【摘要】

：

正电子发射计算机断层扫描(position emission tomography,PET)在临床疾病诊断和治疗监测中具有重要的作用,正电子放射性药物的研究与评价是PET 技术发展的关键。采用LC-MS/MS 技术对非放射性标记的PET 药物进行高通量筛选是当前研究的热点。

【作者】

：

孙明月肖好洪海燕张爱丽张岩刘亚静朱霖 HANK F KUNG 乔晋萍

【机构】

：

北京师范大学化学学院,北京,100875 首都医科大学脑重大疾病研究院,北京,100069

【出处】

：

2018年中国质谱学术大会

【发表日期】

：

2018年7期

【关键词】

：

PET 正电子放射性药物 LC-MS/MS

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

基于质谱技术的良、恶性胸腔积液鉴别诊断的代谢组学研究

目的良、恶性胸腔积液鉴别一直是困扰临床的难题，由于肺癌诱发的恶性胸腔积液与结核诱发的良性胸腔积液有着极为相似的理化特征，亟需采用新的技术手段辅助临床诊治。本研究旨在通过代谢组学的研究方法，运用质谱技术对肺癌、肺结核患者胸腔积液中的代谢轮廓谱进行全面、多维的描述，为临床提供诊断依据。

会议

胸腔积液飞行质谱代谢组学

Quantitative Proteomics Study of the Impact of Titanium Dioxide Nanoparticles on Human Embryonic Ste

The increasing prominence of nanotechnology on the global economy has seen the increased production of new nanoparticles(NPs)[1].

会议

Quantitative proteomicsiTRAQTitanium dioxideNanoparticleHuman embryonic stem

Comprehensive Characterization of Deacetylase-specific Acetylome

Lysine acetylation is a reversible posttranslational modification(PTM)of proteins regulated by lysine acetylases(KATs)and lysine deacetylases(KDACs).

会议

Lysine acetylationDeacetylaseSIRT1HDAC1Acetylome

Profiling and Comparison of toxicant exposure markers in hair and urine samples using mass spectrome

Urine and hair are used for assessing human exposure to toxicants.Urine tests can show toxicant exposure within a few days.

会议

metabolomics profilingurinehairmass spectrometryexposure markers

Investigation of mechanism in Response to Rehydration for Nostoc flagelliforme based on quantitative

To adapt to xeric environments,microorganisms have evolved with the capability of the superior desiccation tolerance and rapid resuscitation after rehydration.

会议

Nostoc flagelliformerehydrationiTRAQphosphorylationextracelluar proteindesi

基于蛋白质组学技术探究左归丸对阴虚热证模型大鼠肝组织蛋白质表达谱的干预和调控

目的：本研究旨在利用蛋白组学技术研究阴虚热证的发病机制及左归丸对阴虚热证的作用机制，并对二者之间的联系进行进一步探究，以实验研究为手段，从药理学及生物学的角度进行探究。

会议

阴虚热证左归丸蛋白质组学干预调控作用机制

Sweetening the Process of Biomarker Discovery in Alzheimer's Disease:Development of Improved Ch

Alzheimers disease(AD)is the most common form of dementia in the elderly population.While several peptide and protein biomarkers in cerebrospinal fluid(CSF)have been used for AD diagnosis,an unequivoc

会议

Glycoproteomicsquantitative proteomicsisobaric taggingbiomarker discoveryAlz

A proteomic investigation of the component and function of royal jelly harvested at different times

Royal jelly(RJ),known as the nutritional source for honeybees and a functional food for humans,is usually harvested within 68~72 h after honeybee worker larvae are transferred into artificial queen ce

会议

Royal JellyGrafting timeProteomeAnti-hypertensiveMembrane protein

Neuropeptidic Regulations are Correlated with Biological Requirements:A Comparison between Apis mell

Pollinators,most often honeybees,play essential roles in maintaining healthy ecosystems and in supporting agricultural production and food security.

会议

NeuropeptidomeHoneybeeApis mellifera ligusticaApis cerana ceranaSocial Behav

Study of Dynamics and Kinetics of β-Lactamases towards Antibiotics by Hydrogen/Deuterium Exchange Ma

Production of β-lactamases renders bacteria invulnerable towards β-lactam antibiotics.The caused antibiotic resistance of bacteria has become a severe health threat worldwide.

会议

Hydrogen/deuterium exchange mass spectrometryextended spectrum β-lactamasesant

LC-MS/MS方法测定大鼠脑中9种非标记PET显像剂的浓度

其他学术论文