【摘 要】
：
The C.elegans p62 homolog, SQST-1, is selectively removed by autophagy.In wild type animals, SQST-1 is weakly expressed and diffusely localized in thecytoplasm.
【机 构】
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StateKeyLaboratoryofBiomacromolecules,InstituteofBiophysics,ChineseAcademyofSciences,Beijing100101,P
【出 处】
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The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
论文部分内容阅读
The C.elegans p62 homolog, SQST-1, is selectively removed by autophagy.In wild type animals, SQST-1 is weakly expressed and diffusely localized in thecytoplasm.In autophagy mutants, levels of SQST-1 are dramatically elevated and SQST-1 accumulates into numerous aggregates.To understand how autophagy activity is regulated, we performed genetic screens to isolate mutants that suppress the accumulation of SQST-1 aggregates in hypomorphic or null mutants of autophagy genes.Here we summarize our screens foratg-7, atg-2, atg-9, epg-5 and epg-7 mutants.Our pioneer screens failed to identify suppressors of epg-9/Atg101 and epg-8/Atg14.
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