Enhanced Remyelinating and Immunomodulatory of Neural Stem Cells by Transduction of Neurotrophin 3

来源 :2013首届世界健康大会 | 被引量 : 0次 | 上传用户：vergillove

【摘要】

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【作者】

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Jingxian Yang Yu Hu Nan Zhang Dong Sun

【机构】

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Liaoning University of Traditional Chinese Medicine China

【出处】

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2013首届世界健康大会

【发表日期】

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2013年12期

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　　The therapeutic potential of neural stem cells (NSCs) on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), has been recently suggested; however, the clinical and pathological improvement is limited.To enhance their therapeutic effect, we in the present study transduced bone marrow derived NSCs (BM-NSCs) with Neurotrophin 3 (NT-3), a potent neurotrophic factor that possesses both neuroprotection and immunomodulation capacities, with a novel Tet-on system to control NT-3 expression.

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