【摘 要】
：
Genetic interactions (GIs) refer to the phenomenon where the phenotype of one gene is affected by another,which are usually related to function.Epistatic mi
【机 构】
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Center for Quantitative Biology,Peking University,Beijing 100871,China
【出 处】
：
中国物理学会2013年秋季学术会议
论文部分内容阅读
Genetic interactions (GIs) refer to the phenomenon where the phenotype of one gene is affected by another,which are usually related to function.Epistatic miniarray profile (E-MAP) is a strategy to generate comprehensive and quantitative genetic interaction maps.By measuring colony size of the mutants,it can quantify genetic interactions.In this study,we generated the genetic interaction networks of cell cycle in budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe by E-MAP,trying to understand the relationships between cell cycle and other cellular events,as well as reveal the conservation and rewiring of cell cycle by comparing the genetic-interaction networks between these two yeast species.
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