Lower urinary tract dysfunction in a pink1 gene knockout rat model for Parkinson's disease

• 作 者: GuitingLin;
• 机 构: Department of Urology, School of Medicine, University of California,San Francisco, CA 94143, USA
• 出 处: GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年
• 发表日期: 2014年期

　　Bladder dysfunction is a common non-motor disorder on Parkinsons disease (PD) patients.A new transgenic Pink1 gene knockout rat model of PD has been developed recently.To explore lower urinary tract function in this newly established PD model and provide possible therapeutic base for PD urinary complications.Twelve Pink1 KO rats (pink1-/-, LEH-pink1tm 1sage, 40 weeks old) and twelve wide type rats (pink1+/+, LEH, 40 weeks old) were used in this project.After acclimation, the rats underwent 24 hours metabolic cage test, conscious cystometry, and leak point pressure test.Their bladders were harvested, weighted and then fixed for histological study.