Regulation of Estrogen Receptor Alpha Level and Hormone Binding Capacity in MCF-7 Breast Cancer Cell

来源 :第五届生命之春论坛 | 被引量 : 0次 | 上传用户：abby412

【摘要】

：

　　Estradiol (E2)-induced growth stimulation of hormone-dependent breast cancer cells is associated with a down regulation of ERα, suggesting that cell prolif

【作者】

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Guy Leclercq Dominique Gallo loanna La(i)os Guy Laurent Yves Jacquot

【机构】

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J.-C.HeusonLaboratoryofBreastCancerologyBorderInstituteBelgium

【出处】

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第五届生命之春论坛

【发表日期】

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2008年6期

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　　Estradiol (E2)-induced growth stimulation of hormone-dependent breast cancer cells is associated with a down regulation of ERα, suggesting that cell proliferation involves an elimination of thereceptor, or at least a decrease of its hormone binding capacity.To assess the validity of this concept, mechanisms underlying the regulation of ERα level were studied, with a special emphasis on the effect of ligands.The MCF-7 breast cancer cell line was selected to conduct our investigations.

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Regulation of Estrogen Receptor Alpha Level and Hormone Binding Capacity in MCF-7 Breast Cancer Cell

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