Pu-erh tea inhibits food uptake and the biosynthesis of fat to reduce fat storage in C.elegans

• 作 者: Xiao-Ju Zou Li-Jiang Yang
• 机 构: DepartmentofLifeScienceandBiotechnology,KunmingUniversity,Kunming650214,China
• 出 处: 第四届全国植物生物技术及其产业化大会
• 发表日期: 2013年5期
• 关键词: Pu-erh tea C.elegans Weight-cutting effects.SREBP Stearoyl-CoA desaturase

　　Pu-erh tea has originally grown and produced in southern of Yunnan, China for more than one thousand years.Consumption of Pu-erh has been thought to possess numerous health benefits including weight-loss, blood lipid lowering effects, and preventing cardiovascular diseases.However, the mechanisms of weight-cutting effect of Pu-erh tea are poorly understood.Here, by using animal model C.elegans, we show that the phyrogenal pumping rate and the uptake of food in Celegans were correspondingly reduced with the increased concentrations of Pu-erh tea.Futhermore, Pu-erh tea down-regulates the expression of the master fat regulator, SREBP, and stearoyl-CoA desaturase that is a key enzyme in the biosythesis of fat in C elegans.Thus, our work demonstrate that Pu-erh tea inhibits food uptake and digestion, as well as down-regulates the biosynthesis of fat to reduce the fat storage.