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Surface-enhanced Raman (SERS) is currently of study interests due to their unique exact, sensitive, and their stability.Novel Gold nanoparticles structural nanomaterials with different shapes, structures and/or controllable components have aroused intense interest in recent years.It has been proved that Gold nanoparticles with sharp edges or branches are more sensitive to the changes in the local dielectric environment and can greatly enhance the surrounding electric field strength, Such as Gold nanostar and Gold nanoflower.So, noble metal nanoparticles especially Gold nanoparticles, as highly biocompatible nanoparticles attracted much attention due to their unusual chemical, electronic and optical properties from protein and DNA detection to cancer therapy and drug delivery, which make them very attractive in a variety of biomedical and technological applications.