【摘 要】
：
Rabies is still a serious public health problem in the developing countries.It is believed that at least 60,000 human deaths occur each year,and more than 10 million people are reported to receive pos
【机 构】
：
Groupe Immuno-Biotechnologie Unité Spécialisée de
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Rabies is still a serious public health problem in the developing countries.It is believed that at least 60,000 human deaths occur each year,and more than 10 million people are reported to receive post-exposure prophylaxis (PEP) every year worldwide.Two types of anti-rabies immunoglobulins (RIG) serum in use are derived from human (HRIG) or equine (ERIG).HRIG are exclusively used in the developed countries.In the developing countries,the large demand for and the cost of HRIG make this treatment modality impractical.In several developing countries ERIG is produced; however,producing large amount of RIG purified from equine sera is not easily achieved because it takes lots of time and effort.Human monoclonal antibodies,which are able to neutralize rabies virus,are a possible alternative to polyclonal human immune serum.However,their obtention remains very tedious.
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