Transporting Proteome and Translation Regulation in CT-26 Cell Educated Mouse Fibroblasts

• 作 者: Shishi Wang Yizhi Cui Zhipeng Chen Lijuan Yang Jiahui Guo Gong Zhang Tong Wang Qing-Yu He
• 机 构: KeyLaboratoryofFunctionalProteinResearchofGuangdongHigherEducationInstitutes,InstituteofLifeandHealt
• 出 处: 第八届中国蛋白质组学大会
• 发表日期: 2013年9期
• 关键词: Tumor microenvironment CEF SILAC translation control

Crosstalk between cancer cells and matrix cells,such as fibroblasts,is a key mechanism of tumor microenvironment formation.In this process,fibroblasts are recognized to be polarized rather to immune cell phenotypes by secreting cancer cell favorable proteins.However,the molecular manifestations responsible for this malignant transformation are unclear.We hypothesize that cancer cells can transport translation-regulating proteins to fibroblasts.