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Despite advances in the development of insulin analogs that have greatly improved the clinical effectiveness of insulin therapy, optimal glycemic control remains elusive and intensive insulin therapy has not gained widespread acceptance in clinical practice.Patients resistance to adopt injectable insulin and adhere to more aggressive insulin regimens significantly limits the goal of achieving glycemic control and better diabetes outcomes.It has been suggested that patients would be more likely to initiate and adhere to insulin therapy if an alternative to the injectable route was available.