Rhein, a natural anthraquinone derivative, ameliorates pancreatic fibrosis in a mouse model of cerul

• 作 者: SiuWaiTsang[1]AlbertSunChiChan[2]ZhaoxiangBian[1]HongjieZhang[1]ChengyuanLin[1]HaitaoXiao[1]MichaelWong[1]HongcaiShang[3]BailiZhang[3]AipingLu[1]KenKin-LamYung[4]
• 机 构: School of Chinese Medicine,Hong Kong Baptist University,Kowloon Tong,Hong Kong SAR,China
• 出 处: 世界中医药学会联合会消化病专业委员会第四届消化病国际学术大会
• 发表日期: 2013年期

　　Anthraquinone possesses diverse biological properties including anti-inflammatory bioactivities.In cerulein-treated mice,application of Rhein (50 mg/kg/day)significantly ameliorated the severity of chronic pancreatitis and the associated fibrogenesis.Pro-inflammatory cytokines and pro-fibrotic mediators were remarkably lowered by the prolonged oral administration of Rhein.Besides anti-inflammatory activities, Rhein actually exerts strong anti-fibrotic properties against the over-production of extracellular matrix and provides effective inhibitory effect on the activation of pancreatic stellate cells.Significance: Rhein has therapeutic potential for the clinical management of pancreatic fibrosis as well as pancreatic stellate cell-related pathologies.