Urinary 6β-Hydroxycortisol/cortisol ratio as a signal of CYP3A4 activity in chinese children acute l

• 作 者: A-JingXu[1]JianZhang[2]YangShu[1]Yue-nianTang[1]YanLiu[1]FangWang[1]LunChen[1]Xiao-TongLu[1]Huai-PingTian[1]Shu-HongBu[1]
• 机 构: Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine,Shanghai, C
• 出 处: 2011年中国药学大会暨第11届中国药师周
• 发表日期: 2011年期

The present study establish a simple method for determining the concentration of 6β-hydroxycortisol and cortisol in urinary at same time, to determined the urinary 6β-hydroxycortisol/cortisol ratio, a marker for CYP3A activity in 13 Chinese children acute lymphoblastic leukemia patients compare with 114 health children. First-morning urine specimen was collected from each subject for the quantification of urinary concentrations of cortisol and 6β-hydroxycortisol. In this study, the association of the 6β-OHC/cortisol ratio was higher in children acute lymphoblastic leukemia patients than in health children, while the 6β-hydroxycortisol/cortisol ratio is no significant different between subgroups in health children (P). These findings suggest that high CYP3A4 activity may be a risk factor for children acute lymphoblastic leukemia risk. 6β-hydroxycortisol/cortisol ratio could be consided as a probe childhood acute lymphoblastic leukemia.