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Background: Methamphetamine (METH), one of amphetamine-type stimulants, is a psychoactive substance widely abused, due to its powerful central nervous system (CNS)stimulation ability.For those who abuse METH, it is not only the mental state but also the structures and the functions of the CNS that have been affected.To date, the available evidence is still not fully to elucidate the precise mechanism of METH neurotoxicity.