Inhibitory Effect of Tranilast on Cytokine,Chemokine,and Adhesion Molecule Expression in Human Corne

来源 :第十七届亚非眼科大会暨中华医学会第十九次全国眼科学术大会 | 被引量 : 0次 | 上传用户：cmcbst

【摘要】

：

【作者】

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Yang Liu Hui Jia Dan Xu Bin He Xiaoru Shi

【机构】

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Department of Ophthalmology,First Hospital of Jilin University,China

【出处】

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第十七届亚非眼科大会暨中华医学会第十九次全国眼科学术大会

【发表日期】

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2014年5期

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Purpose Viral infection of the cornea can result in inflammation and scarring and eventually lead to blindness.Polyinosinic-polycytidylic acid [poly(l:C)], an analog of viral double-stranded RNA, induces the synthesis of various cytokines and chemokines, including interleukin (IL)-6, IL-8 and monocyte chemotactic protein-1 (MCP1), as well as the surface expression of intercellular adhesion molecule-1 (ICAM-1) andvascular endothelial cell adhesion molecule-1 (VCAM-1) in corneal fibroblasts.The effects of tranilast on the expression of these proteins in human corneal fibroblasts were examined.

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Inhibitory Effect of Tranilast on Cytokine,Chemokine,and Adhesion Molecule Expression in Human Corne

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