Multidrug resistance(MDR)is the major obstacle of the success in cancer chemotherapy.The overexpression of ATP-binding cassette(ABC)transporters,particularly ABCB1,ABCC1 and ABCG2,play a significant r
Backgrounds and Purpose: Rapamycin,an mTORC1 allosteric inhibitor with broad antitumor effects,could induce the activation of numerous negative feedback loops such as PI3K/Akt/mTOR signaling pathway,w
Backgroud: Overexpression of c-Myc is associated with worse outcomes in endometrial cancer,indicating that c-Myc may be a promising target for endometrial cancer therapy.A novel small molecule,JQ1,has
Aim: Recent research from our lab has presented evidence that the DNA methylation status of PTPRO is a prognostic factor in ERBB2-positive breast cancer.However,the inherent role of PTPRO in oncogenes