CTGF receptor avβ3 integrins play an important role in myofibroblastic differentiation of hypertroph

• 作 者: Xiao-longHu;Chao-wuTang;Jia-qiLiu;Da-haiHu;Ji-hongShi;Xiao-bingFang;Yao-junWang;NaLi;Xiao-zhiBai;Wei-xiaCai;
• 机 构: Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University,
• 出 处: 第八届全国创伤修复(愈合)与组织再生学术交流会
• 发表日期: 2012年期

　　Connective Tissue Growth Factor (CTGF) is a potent mediator of the differentiation of hypertrophic scar fibroblasts into myofibroblasts,which is characterized by the appearance of the cytoskeletal protein a-smooth muscle actin.The aim of this study was to investigate the role of avβ3 integrins in CTGF-induced myofibroblast differentiation.We show that CTGF induces hypertrophic scar fibroblasts differentiation and collagen synthesis in mRNA and protein level.In this study,we compared the levels of av、β3 integrins between atrophic scar and hypertrophic scar and investigated the association with hypertrophic scar.