Novel compound components of Danshen and Sanqi loaded PLGA nanoparticles for brain delivery via inne

• 作 者: ZHANG Xiao CHEN Gang
• 机 构: Department of Pharmaceutics,School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,
• 出 处: 2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
• 发表日期: 2012年10期
• 关键词: PLGA nanoparticles intratympanic administration brain delivery salvianolic acid

　　Objective:The main goal of this study was to develop novel compound components of Danshen and Sanqi loaded poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) and evaluate their potential in protective effects on brain injury via inner ear administration.Methods:PLGA NPs loaded with salvianolic acid B (Sal B),tanshinone IIA (TS ILA) and panax notoginsenoside (PNS) (notoginsenoside R1 and ginsenoside Rg1,Rb1) were prepared by double emulsion/solvent evaporation method.NPs were