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Oral leukoplakia is a pre-malignant lesion of the oral mucosa.The aim of this study is to compare the curative effects of photodynamic therapy and cryotherapy in the treatment of oral leukoplakia.The first group, treated by photodynamic therapy (-aminolevulinic acid (ALA), 630-635 nm wavelength), consisted of 48 patients suffering from leukoplakia.The second group consisted of 37 patients treated using cryotherapy.Analyses and comparisons of the complete responses, recurrences, numbers of procedures and adverse effects after both PDT and cryotherapy were obtained.In the first group, a complete response was obtained in 35 patients (72.9%), with thirteen recurrences observed (27.1%) over a six-month period.In the second group, a complete response was obtained in 33 patients (89.2%), and recurrence was observed in nine patients (24.3%).Photodynamic therapy and cryotherapy appear to be comparative methods of treatment that may both serve as alternatives for the traditional surgical treatment of oral leukoplakia.The advantages of PDT are connected with minimally invasive and localized character of the treatment and with not damage of collagenous tissue structures, therefore normal cells will repopulate these arrangements.PDT is more convenient for patients, less painful, and more esthetic.