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Cage-like proteins are versatile platforms for developing functional nanomaterials due largely to the following reasons: 1)As the protein cages are gene products,their size and structure are extremely homogeneous,2)The interior cavity of cages can be utilized for templated synthesis of well defined nanoparticles,and 3)They accommodate the introduction of functionality such as cell-targeting capability,either chemically and genetically.We have found that recombinant human H chain ferritin(rHFn),which has a 12 nm exterior diameter and an 8nm interior cavity,is a superior template for biomimetic mineralization and encapsulation of superparamagnetic iron oxide nanoparticles within its interior cavity.